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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
8.48
Human Site:
S786
Identified Species:
12.44
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S786
Q
H
P
Q
P
A
D
S
R
Q
T
G
S
S
K
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S786
Q
H
P
Q
P
A
D
S
R
Q
T
G
P
S
K
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S786
Q
H
P
Q
P
A
D
S
R
Q
T
G
P
S
K
Dog
Lupus familis
XP_546656
989
110956
L786
T
D
S
A
P
R
M
L
P
L
P
A
A
A
D
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
L786
Q
H
N
L
S
Q
P
L
V
N
R
H
T
R
P
Rat
Rattus norvegicus
XP_002742497
1001
111922
L784
Q
R
S
L
S
Q
P
L
V
N
R
H
T
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
P829
Y
N
H
Q
P
R
P
P
P
E
G
R
N
R
P
Chicken
Gallus gallus
NP_001025807
1020
114626
V788
A
N
S
E
N
R
R
V
G
G
T
T
N
M
A
Frog
Xenopus laevis
NP_001085699
1022
114003
R791
M
G
N
S
G
D
G
R
G
R
Q
P
Q
T
K
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
R785
S
S
A
P
P
P
S
R
V
E
N
I
R
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
A788
G
G
G
S
G
R
G
A
G
S
G
G
W
S
S
Honey Bee
Apis mellifera
XP_394050
958
109977
R752
I
R
N
Q
N
I
N
R
N
N
A
M
K
S
R
Nematode Worm
Caenorhab. elegans
O61660
759
85420
A559
M
S
K
P
D
L
R
A
N
L
E
I
G
L
K
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
M479
F
E
P
T
S
L
E
M
V
D
G
Q
T
Q
A
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
F707
Q
L
E
I
P
P
G
F
N
V
N
H
L
G
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
D726
L
G
C
V
G
G
C
D
D
I
L
K
Q
L
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
93.3
6.6
N.A.
13.3
6.6
N.A.
13.3
6.6
6.6
6.6
N.A.
13.3
13.3
6.6
6.6
P-Site Similarity:
100
93.3
93.3
20
N.A.
20
13.3
N.A.
33.3
26.6
20
13.3
N.A.
20
26.6
13.3
20
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
7
0
19
0
13
0
0
7
7
7
7
13
% A
% Cys:
0
0
7
0
0
0
7
0
0
0
0
0
0
0
7
% C
% Asp:
0
7
0
0
7
7
19
7
7
7
0
0
0
0
7
% D
% Glu:
0
7
7
7
0
0
7
0
0
13
7
0
0
0
0
% E
% Phe:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
7
19
7
0
19
7
19
0
19
7
19
25
7
13
0
% G
% His:
0
25
7
0
0
0
0
0
0
0
0
19
0
0
0
% H
% Ile:
7
0
0
7
0
7
0
0
0
7
0
13
0
0
7
% I
% Lys:
0
0
7
0
0
0
0
0
0
0
0
7
7
0
32
% K
% Leu:
7
7
0
13
0
13
0
19
0
13
7
0
7
13
0
% L
% Met:
13
0
0
0
0
0
7
7
0
0
0
7
0
7
0
% M
% Asn:
0
13
19
0
13
0
7
0
19
19
13
0
13
0
0
% N
% Pro:
0
0
25
13
44
13
19
7
13
0
7
7
13
7
25
% P
% Gln:
38
0
0
32
0
13
0
0
0
19
7
7
13
7
0
% Q
% Arg:
0
13
0
0
0
25
13
19
19
7
13
7
7
13
7
% R
% Ser:
7
13
19
13
19
0
7
19
0
7
0
0
7
32
7
% S
% Thr:
7
0
0
7
0
0
0
0
0
0
25
7
19
7
0
% T
% Val:
0
0
0
7
0
0
0
7
25
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _